01122nas a2200169 4500008004100000020001400041245009100055210006900146260001300215300001200228490000600240520059300246100002700839700001700866700002000883856004900903 2015 eng d a1867-245000aTerahertz optical measurements of correlated motions with possible allosteric function0 aTerahertz optical measurements of correlated motions with possib c2015-Jun a201-2160 v73 a
A suggested mechanism for allosteric response is the distortion of the energy landscape with agonist binding changing the protein structure's access to functional configurations. Intramolecular vibrations are indicative of the energy landscape and may have trajectories that enable functional conformational change. Here, we discuss the development of an optical method to measure the intramolecular vibrations in proteins, namely, crystal anisotropy terahertz microscopy, and the various approaches which can be used to identify the spectral data with specific structural motions.
1 aNiessen, Katherine, A.1 aXu, Mengyang1 aMarkelz, A., G. uhttps://markelz.physics.buffalo.edu/node/255