TY - Generic T1 - Terahertz Light Fingerprints Biomolecular Dynamics T2 - CLEO: Science and Innovations Y1 - 2018 A1 - Deng, Yanting A1 - Xu, Mengyang A1 - Niessen, Katherine A A1 - George, Deepu Koshy A1 - Markelz, Andrea G JF - CLEO: Science and Innovations PB - Optical Society of America ER - TY - JOUR T1 - Terahertz optical measurements of correlated motions with possible allosteric function JF - Biophysical Reviews Y1 - 2015 A1 - Niessen, Katherine A. A1 - Xu, Mengyang A1 - Markelz, A. G. AB -

A suggested mechanism for allosteric response is the distortion of the energy landscape with agonist binding changing the protein structure's access to functional configurations. Intramolecular vibrations are indicative of the energy landscape and may have trajectories that enable functional conformational change. Here, we discuss the development of an optical method to measure the intramolecular vibrations in proteins, namely, crystal anisotropy terahertz microscopy, and the various approaches which can be used to identify the spectral data with specific structural motions.

VL - 7 SN - 1867-2450 N1 - 19 ER -