%0 Patent %D 2021 %T Apparatus and method for analyzing a sample %A Markelz, Andrea G %A Acbas, Gheorghe %A Niessen, Katherine A. %X
An apparatus and method for Crystal Anisotropy Terahertz Microscopy (“CATM”) is provided. The apparatus includes an emitter configured to emit a THz pulse and a detector configured to detect the THz pulse after the pulse is transmitted through a sample disposed on a sample surface of the detector. A pulsed radiation generator generates a probe beam to interrogate the detector. The detector may include an electro-optical (“EO”) crystal configured to change in birefringence according to the THz pulse. The sample surface of the detector may have a dielectric coating which is transmissive to THz and reflective to the probe beam. The sample is disposed on the dielectric coating.
%I USPTO %C United States %G eng %U https://patents.google.com/patent/US11125685B2/en %0 Journal Article %J Nature communications %D 2019 %T Protein and RNA dynamical fingerprinting %A Niessen, Katherine A %A Xu, Mengyang %A George, Deepu K %A Chen, Michael C %A Ferré-D’Amaré, Adrian R %A Snell, Edward H %A Cody, Vivian %A Pace, James %A Schmidt, Marius %A Markelz, Andrea G %B Nature communications %V 10 %P 1-10 %@ 2041-1723 %G eng %R https://doi.org/10.1038/s41467-019-08926-3 %0 Conference Proceedings %B CLEO: Science and Innovations %D 2018 %T Terahertz Light Fingerprints Biomolecular Dynamics %A Deng, Yanting %A Xu, Mengyang %A Niessen, Katherine A %A George, Deepu Koshy %A Markelz, Andrea G %B CLEO: Science and Innovations %I Optical Society of America %P SW3D. 5 %G eng %R https://doi.org/10.1364/CLEO_SI.2018.SW3D.5 %0 Journal Article %J Biophysical Journal %D 2017 %T Moving in the right direction: protein vibrations steering function %A Niessen, Katherine A %A Xu, Mengyang %A Paciaroni, Alessandro %A Orecchini, Andrea %A Snell, Edward H %A Markelz, Andrea G %B Biophysical Journal %V 112 %P 933-942 %@ 0006-3495 %G eng %R https://doi.org/10.1016/j.bpj.2016.12.049 %0 Journal Article %J IEEE Transactions on Terahertz Science and Technology %D 2013 %T Photoactive yellow protein terahertz response: hydration, heating and intermediate states %A George, Deepu K %A Knab, Joseph R %A He, Yunfen %A Kumauchi, Masato %A Birge, Robert R %A Hoff, Wouter D %A Markelz, Andrea G %B IEEE Transactions on Terahertz Science and Technology %V 3 %P 288-294 %@ 2156-342X %G eng %R https://doi.org/10.1109/TTHZ.2013.2256233 %0 Journal Article %J The Journal of Physical Chemistry A %D 2012 %T Improved mode assignment for molecular crystals through anisotropic terahertz spectroscopy %A Singh, Rohit %A George, Deepu Koshy %A Benedict, Jason B %A Korter, Timothy M %A Markelz, Andrea G %B The Journal of Physical Chemistry A %V 116 %P 10359-10364 %@ 1089-5639 %G eng %R https://doi.org/10.1021/jp307288r %0 Journal Article %J JOSA BJOSA B %D 2012 %T Terahertz magneto-optical polarization modulation spectroscopy %A George, Deepu K %A Stier, Andreas V %A Ellis, Chase T %A McCombe, Bruce D %A Černe, John %A Markelz, Andrea G %B JOSA BJOSA B %V 29 %P 1406-1412 %@ 1520-8540 %G eng %R https://doi.org/10.1364/JOSAB.29.001406 %0 Journal Article %J Journal of Infrared, Millimeter, and Terahertz Waves %D 2012 %T Terahertz spectroscopic analysis of peptides and proteins %A Falconer, Robert J %A Markelz, Andrea G %B Journal of Infrared, Millimeter, and Terahertz Waves %V 33 %P 973-988 %@ 1866-6892 %G eng %R https://doi.org/10.1007/s10762-012-9915-9 %0 Journal Article %J Biophysical Journal %D 2011 %T Evidence of protein collective motions on the picosecond timescale %A He, Yunfen %A Chen, J-Y %A Knab, Joseph R %A Zheng, Wenjun %A Markelz, Andrea G %B Biophysical Journal %V 100 %P 1058-1065 %@ 0006-3495 %G eng %R https://dx.doi.org/10.1016%2Fj.bpj.2010.12.3731 %0 Conference Proceedings %B 2008 33rd International Conference on Infrared, Millimeter and Terahertz Waves %D 2008 %T The role of structure in the protein dynamical transition %A He, Yunfen %A Markelz, Andrea G %B 2008 33rd International Conference on Infrared, Millimeter and Terahertz Waves %I IEEE %P 1-3 %@ 1424421195 %G eng %R https://doi.org/10.1109/ICIMW.2008.4665800 %0 Journal Article %J IEEE Journal of Selected Topics in Quantum Electronics %D 2008 %T Terahertz dielectric sensitivity to biomolecular structure and function %A Markelz, Andrea G %B IEEE Journal of Selected Topics in Quantum Electronics %V 14 %P 180-190 %@ 1077-260X %G eng %R https://doi.org/10.1109/JSTQE.2007.913424 %0 Journal Article %J Proceedings of the IEEE %D 2007 %T Terahertz measurements of protein relaxational dynamics %A Knab, Joseph R %A Chen, Jing-Yin %A He, Yunfen %A Markelz, Andrea G %B Proceedings of the IEEE %V 95 %P 1605-1610 %@ 0018-9219 %G eng %R 10.1109/JPROC.2007.898906 %0 Conference Proceedings %B 2006 Joint 31st International Conference on Infrared Millimeter Waves and 14th International Conference on Teraherz Electronics %D 2006 %T Protein conformational dynamics measured with terahertz time domain spectroscopy %A Knab, Joseph R %A Chen, Jing-Yin %A Ye, Shuji %A He, Yunfen %A Markelz, Andrea G %B 2006 Joint 31st International Conference on Infrared Millimeter Waves and 14th International Conference on Teraherz Electronics %I IEEE %P 183-183 %@ 1424403995 %G eng %R https://doi.org/10.1088/0031-9155/47/21/318 %0 Conference Proceedings %B Terahertz for military and security applications Ii %D 2004 %T Tagless and universal biosensor for point detection of pathogens %A Markelz, Andrea G %A Knab, Joseph R %A Chen, Jing-Yin %A Černe, John %A Cox, William A %B Terahertz for military and security applications Ii %I International Society for Optics and Photonics %V 5411 %P 182-186 %G eng %R https://doi.org/10.1117/12.563613 %0 Journal Article %J International Journal of High Speed Electronics and Systems %D 2003 %T Terahertz applications to biomolecular sensing %A Markelz, Andrea G %A Whitmire, Scott E %B International Journal of High Speed Electronics and Systems %V 13 %P 951-967 %@ 0129-1564 %G eng %R https://doi.org/10.1142/S0129156403002101