@proceedings {544, title = {Stabilization of Terahertz Vibrational Modes in Illuminated Orange Carotenoid Protein Crystals}, year = {2020}, address = {Buffalo, NY}, abstract = {

Orange carotenoid protein (OCP) controls efficiency of the phycobilisome (PBS), the light harvesting antenna in cyanobacteria, to prevent oxidative damage. The OCP switches from resting state to photo protective state with intense blue light illumination. Questions persist as to why OCPR interaction increases with the PBS over that with the OCPO. Here we examine the role of long-range intramolecular vibrations within OCP. Using Stationary Sample Anisotropic Terahertz Microscopy (SSATM) we measure changes in the intramolecular vibrations with photo switching. We report the first observation of switching in the intramolecular vibrations with photoexcitation. Results suggest that there is a stiffening of the molecule in the photo protective state. This increase in structural stability may enhance the interaction with the PBS change in OCP interaction with PBS. In low light, carotenoid bound OCP appears orange (OCP o ) and is inactive. Illumination by strong light converts OCP to the active, red (OCPR) state, which interacts with the PBS. A comparison of anisotropic THz microscopy measurements of dark adapted (OCP o ) and illuminated OCP crystals indicate differences in their vibrational modes that may be important for OCP-PBS interactions.

}, doi = {10.1109/IRMMW-THz46771.2020.9370827}, author = {McKinney, J. and Sharma, A. and Deng, Y. and George, D. and Lechno-Yossef, S. and Kerfeld, C. and Markelz, A.} } @article {276, title = {Blue Shift of a Molecular Crystal Phonon at the Solid to Liquid Phase Transition}, journal = {Bulletin of the American Physical Society}, volume = {2019}, year = {2019}, author = {Davie, Alex and Vandrevala, Farah and Deng, Yanting and George, D. and Sylvester, Eric D. and Korter, T. and Einarsson, E. and Benedict, Jason B. and Markelz, Andrea} } @article {251, title = {The Effect of Crystal Contact Forces on the Protein Global Motions}, journal = {Biophysical Journal}, volume = {116}, number = {3}, year = {2019}, note = {ISI Document Delivery No.: HO2XG
Times Cited: 0
Cited Reference Count: 1
Cited References:
Acbas G, 2014, NAT COMMUN, V5, DOI 10.1038/ncomms4076
McKinney, Jeffrey A. Deng, Yanting George, Deepu Markelz, Andrea
63rd Annual Meeting of the Biophysical-Society
Mar 02-06, 2019
Baltimore, MD
Biophys Soc

8
Cell press
Cambridge
1542-0086
1}, month = {Feb}, pages = {489A-489A}, type = {Meeting Abstract}, keywords = {Biophysics}, isbn = {0006-3495}, doi = {10.1016/j.bpj.2018.11.2638}, author = {McKinney, J. A. and Deng, Y. T. and George, D. and Markelz, A.} } @proceedings {244, title = {Magneto Optical Polarization Measurements using THz Polarization Modulation Spectroscopy}, year = {2011}, note = {ISI Document Delivery No.: BJT73
Times Cited: 0
Cited Reference Count: 3
Cited References:
Cerne J, 2000, PHYS REV B, V61, P8133, DOI 10.1103/PhysRevB.61.8133
Crassee I, 2011, NAT PHYS, V7, P48, DOI 10.1038/NPHYS1816
Tse WK, 2010, PHYS REV LETT, V105, DOI 10.1103/PhysRevLett.105.057401
Stier, A. V. George, D. Markelz, A. G. Cerne, J.
Irmmw-thz
Proceedings Paper
36th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)
Oct 02-07, 2011
Houston, TX
Rice Univ, IEEE Microwave Theory \& Tech Soc, NASA, California Inst Technol, Jet Prop Lab, Univ Wollongong
George, Deepu/J-9882-2014
George, Deepu/0000-0003-0021-0705
345 e 47th st, new york, ny 10017 usa
2162-2027}, publisher = {Ieee}, address = {New York}, abstract = {

We report a new broad band technique for rapidly measuring the complex Faraday and Kerr rotations in materials such as topological insulators and graphene, combining the distinct advantages of THz time domain spectroscopy and polarization modulation techniques. The performance of the system is demonstrated using GaAs two dimensional electron gas in a magnetic field.

}, isbn = {978-1-4577-0509-0}, doi = {10.1364/JOSAB.29.001406}, author = {Stier, A. V. and George, D. and Markelz, A. G. and Cerne, J.}, editor = {Koch, M.} } @conference {330, title = { Characterization of Phonons in Molecular Crystals }, booktitle = {Frontiers in Optics 2010}, year = {2010}, month = {10/2010}, address = {Rochester}, abstract = {

We demonstrate a new technique for characterizing the phonons in molecular crystals, Modulated Orientation Sensitive Terahertz Spectroscopy (MOSTS). The technique suppresses crystal defects and solvent contributions, and enhances contributions due to molecular structure and anisotropy.

}, doi = {10.1364/FIO.2010.JWA19}, author = {Singh, R. and George, D. and Markelz, A. G.} } @proceedings {232, title = {The role of the protein surface on the local biological water dynamics}, volume = {7397}, year = {2009}, note = {ISI Document Delivery No.: BVQ85
Times Cited: 0
Cited Reference Count: 12
Cited References:
Balu R, 2008, BIOPHYS J, V94, P3217, DOI 10.1529/biophysj.107.105163
Bergner A, 2005, REV SCI INSTRUM, V76, DOI 10.1063/1.1928427
Born B, 2009, J AM CHEM SOC, V131, P3752, DOI 10.1021/ja808997y
Chen JY, 2007, APPL PHYS LETT, V90, DOI 10.1063/1.2748852
He YF, 2008, PHYS REV LETT, V101, DOI 10.1103/PhysRevLett.101.178103
Heugen U, 2006, P NATL ACAD SCI USA, V103, P12301, DOI 10.1073/pnas.0604897103
Jepsen PU, 2007, OPT EXPRESS, V15, P14717, DOI 10.1364/OE.15.014717
Kindt JT, 1996, J PHYS CHEM-US, V100, P10373, DOI 10.1021/jp960141g
Knab J, 2006, BIOPHYS J, V90, P2576, DOI 10.1529/biophysj.105.069088
THRANE L, 1995, CHEM PHYS LETT, V240, P330, DOI 10.1016/0009-2614(95)00543-D
Xu J, 2006, J CHEM PHYS, V124, DOI 10.1063/1.2151267
Yada H, 2008, CHEM PHYS LETT, V464, P166, DOI 10.1016/j.cplett.2008.09.015
Liang, Wei He, Yunfen George, Deepu Markelz, A. G.
Proceedings Paper
Conference on Biosensing II
Aug 04-06, 2009
San Diego, CA
Spie
George, Deepu/J-9882-2014
George, Deepu/0000-0003-0021-0705; Markelz, Andrea/0000-0003-0443-4319
1000 20th st, po box 10, bellingham, wa 98227-0010 usa
0277-786x
73970t}, publisher = {Spie-Int Soc Optical Engineering}, address = {Bellingham}, abstract = {

Protein function is reliant on structural flexibility and this flexibility is slaved to the surrounding solvent. Here we discuss how the exposed surface of the protein influences the solvent dynamics and thereby influences the protein{\textquoteright}s own structural dynamics. We discuss measurements of the THz absorption of water in the presence of hydrophilic and hydrophobic surfaces.

}, keywords = {alanine, dynamics, hydration, lysine, lysozyme, proteins, relaxation, spectroscopy, Terahertz, thz}, isbn = {978-0-8194-7687-6}, doi = {https://doi.org/10.1117/12.828697}, author = {Liang, W. and He, Y. F. and George, D. and Markelz, A. G.}, editor = {Razeghi, M. and Mohseni, H.} }