@proceedings {232, title = {The role of the protein surface on the local biological water dynamics}, volume = {7397}, year = {2009}, note = {ISI Document Delivery No.: BVQ85
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Liang, Wei He, Yunfen George, Deepu Markelz, A. G.
Proceedings Paper
Conference on Biosensing II
Aug 04-06, 2009
San Diego, CA
Spie
George, Deepu/J-9882-2014
George, Deepu/0000-0003-0021-0705; Markelz, Andrea/0000-0003-0443-4319
1000 20th st, po box 10, bellingham, wa 98227-0010 usa
0277-786x
73970t}, publisher = {Spie-Int Soc Optical Engineering}, address = {Bellingham}, abstract = {

Protein function is reliant on structural flexibility and this flexibility is slaved to the surrounding solvent. Here we discuss how the exposed surface of the protein influences the solvent dynamics and thereby influences the protein{\textquoteright}s own structural dynamics. We discuss measurements of the THz absorption of water in the presence of hydrophilic and hydrophobic surfaces.

}, keywords = {alanine, dynamics, hydration, lysine, lysozyme, proteins, relaxation, spectroscopy, Terahertz, thz}, isbn = {978-0-8194-7687-6}, doi = {https://doi.org/10.1117/12.828697}, author = {Liang, W. and He, Y. F. and George, D. and Markelz, A. G.}, editor = {Razeghi, M. and Mohseni, H.} } @article {223, title = {Terahertz dielectric assay of solution phase protein binding}, journal = {Applied Physics Letters}, volume = {90}, number = {24}, year = {2007}, note = {ISI Document Delivery No.: 179QR
Times Cited: 51
Cited Reference Count: 9
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Chen, Jing-Yin Knab, J. R. Ye, Shuji He, Yunfen Markelz, A. G.
Ye, Shuji/B-4479-2010
Markelz, Andrea/0000-0003-0443-4319
53
1
42
Amer inst physics
Melville
1077-3118}, month = {Jun}, pages = {3}, type = {Article}, abstract = {

The authors demonstrate a method for rapid determination of protein-ligand binding on solution phase samples using terahertz dielectric spectroscopy. Measurements were performed using terahertz time domain spectroscopy on aqueous solutions below the liquid-solid transition for water. Small ligand binding sensitivity was demonstrated using triacetylglucosamine and hen egg white lysozyme with a decrease in dielectric response with binding. The magnitude of the change increases with frequency. (c) 2007 American Institute of Physics.

}, keywords = {dynamics, lysozyme, Physics, spectroscopy, water}, isbn = {0003-6951}, doi = {10.1063/1.2748852}, author = {Chen, J. Y. and Knab, J. R. and Ye, S. J. and He, Y. F. and Markelz, A. G.} }