@proceedings {308, title = {Ultrafast Carriers Dynamics in GaSb/Mn Random Alloys}, year = {2006}, address = {Vienna Austria}, doi = {10.1063/1.2730382}, author = {Ye, S. and Knab, J. and Chen, J.-Y. and Wang, S. and Cheon, M. and Luo, H. and Markelz, A. G.} } @proceedings {309, title = {Using terahertz spectroscopy as a protein binding assay}, volume = {Proc SPIE 6080,}, year = {2006}, month = {02/2006}, pages = {35-42}, address = { San Jose, California, United States}, abstract = {

The vibrational modes corresponding to protein tertiary structural motion lay in the far infrared or terahertz frequency range. These collective large scale motions depend on global structure and thus will necessarily be perturbed by ligand binding events. We discuss the use of terahertz dielectric spectroscopy to measure these vibrational modes and the sensitivity of the technique to changes in protein conformation, oxidation state and environment. A challenge of applying this sensitivity as a spectroscopic assay for ligand binding is the sensitivity of the technique to both bulk water and water bound to the protein. This sensitivity can entirely obscure the signal from the protein or protein-ligand complex itself, thus necessitating sophisticated sample preparation making the technique impractical for industrial applications. We discuss methods to overcome this background and demonstrate how terahertz spectroscopy can be used to quickly assay protein binding for proteomics and pharmaceutical research.

}, doi = {10.1117/12.664098}, author = {Chen, J.-Y. and Knab, J. R. and Ye, S. and He, Y. and Markelz, A. G.} } @proceedings {315, title = {Ultrafast THz spectroscopy of photoactive biomolecules}, year = {2003}, month = {01/2003}, pages = {146-153}, address = {San Jose, California}, author = {Chen, J.-Y. and Whitmire, S. E. and Markelz, A. G. and Hillebrecht, J. R. and Birge, R. R.} } @article {265, title = {Undressing a collective intersubband excitation in a quantum well}, journal = {Physical Review Letters}, volume = {76}, number = {13}, year = {1996}, note = {Sherwin, Mark S/Q-4762-2017
Sherwin, Mark S/0000-0002-3869-1893; Markelz, Andrea/0000-0003-0443-4319
78}, month = {Mar 25}, pages = {2382-2385}, abstract = {

We have experimentally measured the 1-2 intersubband absorption in a single 40 nm wide modulation-doped Al0.3Ga0.7As/GaAs square quantum well as a function of frequency, intensity, and charge density. The low-intensity depolarization-shifted absorption occurs near 80 cm(-1) (10 meV or 2.4 THz), nearly 30\% higher than the intersubband spacing. At higher intensities, the absorption peak shifts to lower frequencies. Our data are in good agreement with a theory proposed by Zaluzny, which attributes the redshift to a reduction in the depolarization shift as the excited subband becomes populated.

}, isbn = {0031-9007}, doi = {10.1103/PhysRevLett.76.2382}, author = {Craig, K. and Galdrikian, B. and Heyman, J. N. and Markelz, A. G. and Williams, J. B. and Sherwin, M. S. and Campman, K. and Hopkins, P. F. and Gossard, A. C.} }