@article {263, title = {Large oxidation dependence observed in terahertz dielectric response for cytochrome c}, journal = {Physical Review E}, volume = {72}, number = {4}, year = {2005}, note = {ISI Document Delivery No.: 979GO
Times Cited: 51
Cited Reference Count: 29
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Chen, JY Knab, JR Cerne, J Markelz, AG
Markelz, Andrea/0000-0003-0443-4319
52

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Amer physical soc
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1}, month = {Oct}, pages = {4}, type = {Article}, abstract = {

Far infrared dielectric response is used to characterize the collective mode density of states for cytochrome c as a function of oxidation state and hydration using terahertz time domain spectroscopy. A strong absorbance and refractive index increase was observed with the oxidation. A simple phenomenological fitting using a continuous distribution of oscillators reproduces the frequency dependence of the complex dielectric response as well as demonstrates quantitative agreement with a uniform increase in either mode density or polarizability with oxidation in the 5-80 cm(-1) frequency range. Hydration dependence measurements find that a difference in the equilibrium water content for ferri and ferro cytochrome c is not sufficient to account for the large change in terahertz response. The large dielectric increase at terahertz frequencies with oxidation suggests either a significant global softening of the potential and/or a significant increase in polarizability with oxidation.

}, keywords = {absorption, binding, conformation, dna, dynamics, heart ferricytochrome-c, modes, Physics, protein flexibility, spectroscopy, state}, isbn = {1539-3755}, doi = {10.1103/PhysRevE.72.040901}, author = {Chen, J. Y. and Knab, J. R. and Cerne, J. and Markelz, A. G.} }