<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Acbas, G.</style></author><author><style face="normal" font="default" size="100%">Niessen, K. A.</style></author><author><style face="normal" font="default" size="100%">Snell, E. H.</style></author><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Optical measurements of long-range protein vibrations</style></title><secondary-title><style face="normal" font="default" size="100%">Nature Communications</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Nat. Commun.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">absorption</style></keyword><keyword><style  face="normal" font="default" size="100%">crystals</style></keyword><keyword><style  face="normal" font="default" size="100%">dynamics</style></keyword><keyword><style  face="normal" font="default" size="100%">frequency raman-spectra</style></keyword><keyword><style  face="normal" font="default" size="100%">hydration</style></keyword><keyword><style  face="normal" font="default" size="100%">lysozyme</style></keyword><keyword><style  face="normal" font="default" size="100%">motions</style></keyword><keyword><style  face="normal" font="default" size="100%">Science &amp; Technology - Other Topics</style></keyword><keyword><style  face="normal" font="default" size="100%">sensitivity</style></keyword><keyword><style  face="normal" font="default" size="100%">simulations</style></keyword><keyword><style  face="normal" font="default" size="100%">spectroscopy</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2014</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Jan</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">7</style></pages><isbn><style face="normal" font="default" size="100%">2041-1723</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;Protein biological function depends on structural flexibility and change. From cellular communication through membrane ion channels to oxygen uptake and delivery by haemoglobin, structural changes are critical. It has been suggested that vibrations that extend through the protein play a crucial role in controlling these structural changes. While nature may utilize such long-range vibrations for optimization of biological processes, bench-top characterization of these extended structural motions for engineered biochemistry has been elusive. Here we show the first optical observation of long-range protein vibrational modes. This is achieved by orientation-sensitive terahertz near-field microscopy measurements of chicken egg white lysozyme single crystals. Underdamped modes are found to exist for frequencies &amp;gt;10 cm(-1). The existence of these persisting motions indicates that damping and intermode coupling are weaker than previously assumed. The methodology developed permits protein engineering based on dynamical network optimization.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><accession-num><style face="normal" font="default" size="100%">WOS:000331084200018</style></accession-num><notes><style face="normal" font="default" size="100%">ISI Document Delivery No.: AA4RQ&lt;br/&gt;Times Cited: 101&lt;br/&gt;Cited Reference Count: 48&lt;br/&gt;Cited References: &lt;br/&gt;     AUSTIN RH, 1989, PHYS REV LETT, V62, P1912, DOI 10.1103/PhysRevLett.62.1912&lt;br/&gt;     Bahar I, 2005, CURR OPIN STRUC BIOL, V15, P586, DOI 10.1016/j.sbi.2005.08.007&lt;br/&gt;     Balabin IA, 2000, SCIENCE, V290, P114, DOI 10.1126/science.290.5489.114&lt;br/&gt;     Balog E, 2004, PHYS REV LETT, V93, DOI 10.1103/PhysRevLett.93.028103&lt;br/&gt;     Barth A, 2002, Q REV BIOPHYS, V35, P369, DOI 10.1017/S0033583502003815&lt;br/&gt;     Benkovic SJ, 2003, SCIENCE, V301, P1196, DOI 10.1126/science.1085515&lt;br/&gt;     Brooks BR, 2009, J COMPUT CHEM, V30, P1545, DOI 10.1002/jcc.21287&lt;br/&gt;     BROOKS BR, 1983, J COMPUT CHEM, V4, P187, DOI 10.1002/jcc.540040211&lt;br/&gt;     Brooks CL, 1988, PROTEINS THEORETICAL&lt;br/&gt;     Chen JY, 2007, APPL PHYS LETT, V90, DOI 10.1063/1.2748852&lt;br/&gt;     Chen JY, 2005, PHYS REV E, V72, DOI 10.1103/PhysRevE.72.040901&lt;br/&gt;     Ding T, 2012, VIB SPECTROSC, V61, P144, DOI 10.1016/j.vibspec.2012.02.020&lt;br/&gt;     GENZEL L, 1976, BIOPOLYMERS, V15, P219, DOI 10.1002/bip.1976.360150115&lt;br/&gt;     George DK, 2013, IEEE T THZ SCI TECHN, V3, P288, DOI 10.1109/TTHZ.2013.2256233&lt;br/&gt;     GRISCHKOWSKY D, 1990, J OPT SOC AM B, V7, P2006, DOI 10.1364/JOSAB.7.002006&lt;br/&gt;     Hafner J, 2011, J CHEM PHYS, V135, DOI 10.1063/1.3646312&lt;br/&gt;     Hammes GG, 2002, BIOCHEMISTRY-US, V41, P8221, DOI 10.1021/bi0260839&lt;br/&gt;     He YF, 2011, BIOPHYS J, V100, P1058, DOI 10.1016/j.bpj.2010.12.3731&lt;br/&gt;     KACHALOVA GS, 1991, FEBS LETT, V284, P91, DOI 10.1016/0014-5793(91)80769-Y&lt;br/&gt;     Karplus M, 2005, P NATL ACAD SCI USA, V102, P6679, DOI 10.1073/pnas.0408930102&lt;br/&gt;     Knab J, 2006, BIOPHYS J, V90, P2576, DOI 10.1529/biophysj.105.069088&lt;br/&gt;     Knab JR, 2010, APPL PHYS LETT, V97, DOI 10.1063/1.3467192&lt;br/&gt;     LEVY RM, 1984, J PHYS CHEM-US, V88, P4233, DOI 10.1021/j150663a009&lt;br/&gt;     Lipps F, 2012, PHYS CHEM CHEM PHYS, V14, P6375, DOI 10.1039/c2cp23760a&lt;br/&gt;     Liu D, 2008, PHYS REV LETT, V101, DOI 10.1103/PhysRevLett.101.135501&lt;br/&gt;     MacKerell AD, 1998, J PHYS CHEM B, V102, P3586, DOI 10.1021/jp973084f&lt;br/&gt;     Markelz AG, 2008, IEEE J SEL TOP QUANT, V14, P180, DOI 10.1109/JSTQE.2007.913424&lt;br/&gt;     Meinhold L, 2007, PHYS REV LETT, V99, DOI 10.1103/PhysRevLett.99.138101&lt;br/&gt;     Meinhold L, 2007, PROTEINS, V66, P941, DOI 10.1002/prot.21246&lt;br/&gt;     Mittleman D.M., 2003, SENSING TERAHERTZ RA&lt;br/&gt;     MOELLER KD, 1992, BIOPHYS J, V61, P276, DOI 10.1016/S0006-3495(92)81834-9&lt;br/&gt;     Perutz MF, 1998, ANNU REV BIOPH BIOM, V27, P1, DOI 10.1146/annurev.biophys.27.1.1&lt;br/&gt;     Planken PCM, 2011, J INFRARED MILLIM TE, V32, P975, DOI 10.1007/s10762-011-9824-3&lt;br/&gt;     Rheinstadter MC, 2009, PHYS REV LETT, V103, DOI 10.1103/PhysRevLett.103.128104&lt;br/&gt;     Sakai K., 2005, TERAHERTZ OPTOELECTR&lt;br/&gt;     Schumacher M, 2002, NATURE, V417, P501, DOI 10.1038/417501a&lt;br/&gt;     Siegrist K, 2006, J AM CHEM SOC, V128, P5764, DOI 10.1021/ja058176u&lt;br/&gt;     Singh R, 2012, J PHYS CHEM A, V116, P10359, DOI 10.1021/jp307288r&lt;br/&gt;     SMITH J, 1990, J CHEM PHYS, V93, P2974, DOI 10.1063/1.458885&lt;br/&gt;     SMITH JC, 1991, Q REV BIOPHYS, V24, P227, DOI 10.1017/S0033583500003723&lt;br/&gt;     TEETER MM, 1990, J PHYS CHEM-US, V94, P8091, DOI 10.1021/j100384a021&lt;br/&gt;     TIDOR B, 1994, J MOL BIOL, V238, P405, DOI 10.1006/jmbi.1994.1300&lt;br/&gt;     Tych KM, 2011, J APPL CRYSTALLOGR, V44, P129, DOI 10.1107/S0021889810043372&lt;br/&gt;     Urabe H, 1998, BIOPHYS J, V74, P1533, DOI 10.1016/S0006-3495(98)77865-8&lt;br/&gt;     Walther M, 2003, CHEM PHYS, V288, P261, DOI 10.1016/S0301-0104(03)00031-4&lt;br/&gt;     WU Q, 1995, APPL PHYS LETT, V67, P3523, DOI 10.1063/1.114909&lt;br/&gt;     Xie AH, 2002, PHYS REV LETT, V88, DOI 10.1103/PhysRevLett.88.018102&lt;br/&gt;     Xu J, 2006, J PHYS CHEM B, V110, P24255, DOI 10.1021/jp064830w&lt;br/&gt;Acbas, Gheorghe Niessen, Katherine A. Snell, Edward H. Markelz, A. G.&lt;br/&gt;Snell, Edward/G-2055-2018&lt;br/&gt;Snell, Edward/0000-0001-8714-3191; Markelz, Andrea/0000-0003-0443-4319&lt;br/&gt;National Science Foundation MRIboolean AND2 grant [DBI2959989]&lt;br/&gt;We thank Yunfen He and Benjamin Keen for their assistance with calculations. All calculations performed using facilities provided by The Center for Computational Research, SUNY, Buffalo. We thank the National Science Foundation MRI boolean AND 2 grant DBI2959989 for support.&lt;br/&gt;101&lt;br/&gt;4&lt;br/&gt;108&lt;br/&gt;Nature publishing group&lt;br/&gt;London</style></notes><custom7><style face="normal" font="default" size="100%">3076</style></custom7><auth-address><style face="normal" font="default" size="100%">[Acbas, Gheorghe|Niessen, Katherine A.|Markelz, A. G.] SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA. [Snell, Edward H.|Markelz, A. G.] SUNY Buffalo, Hauptman Woodward Med Res Inst, Dept Biol Struct, Buffalo, NY 14203 USA.&lt;br/&gt;Markelz, AG (corresponding author), SUNY Buffalo, Dept Phys, 239 Fronczak Hall, Buffalo, NY 14260 USA.&lt;br/&gt;amarkelz@buffalo.edu</style></auth-address></record></records></xml>