<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Balu, R.</style></author><author><style face="normal" font="default" size="100%">Zhang, H.</style></author><author><style face="normal" font="default" size="100%">Zukowski, E.</style></author><author><style face="normal" font="default" size="100%">Chen, J. Y.</style></author><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author><author><style face="normal" font="default" size="100%">Gregurick, S. K.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Terahertz spectroscopy of bacteriorhodopsin and rhodopsin: Similarities and differences</style></title><secondary-title><style face="normal" font="default" size="100%">Biophysical Journal</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Biophys. J.</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Biophysics</style></keyword><keyword><style  face="normal" font="default" size="100%">bovine rhodopsin</style></keyword><keyword><style  face="normal" font="default" size="100%">conformational-changes</style></keyword><keyword><style  face="normal" font="default" size="100%">elastic</style></keyword><keyword><style  face="normal" font="default" size="100%">frequency normal-modes</style></keyword><keyword><style  face="normal" font="default" size="100%">light activation</style></keyword><keyword><style  face="normal" font="default" size="100%">molecular-dynamics simulation</style></keyword><keyword><style  face="normal" font="default" size="100%">neutron-scattering</style></keyword><keyword><style  face="normal" font="default" size="100%">protein-coupled receptors</style></keyword><keyword><style  face="normal" font="default" size="100%">transmembrane helices</style></keyword><keyword><style  face="normal" font="default" size="100%">vibrational-modes</style></keyword><keyword><style  face="normal" font="default" size="100%">wild-type</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2008</style></year><pub-dates><date><style  face="normal" font="default" size="100%">Apr</style></date></pub-dates></dates><number><style face="normal" font="default" size="100%">8</style></number><volume><style face="normal" font="default" size="100%">94</style></volume><pages><style face="normal" font="default" size="100%">3217-3226</style></pages><isbn><style face="normal" font="default" size="100%">0006-3495</style></isbn><language><style face="normal" font="default" size="100%">English</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We studied the low-frequency terahertz spectroscopy of two photoactive protein systems, rhodopsin and bacteriorhodopsin, as a means to characterize collective low-frequency motions in helical transmembrane proteins. From this work, we found that the nature of the vibrational motions activated by terahertz radiation is surprisingly similar between these two structurally similar proteins. Specifically, at the lowest frequencies probed, the cytoplasmic loop regions of the proteins are highly active; and at the higher terahertz frequencies studied, the extracellular loop regions of the protein systems become vibrationally activated. In the case of bacteriorhodopsin, the calculated terahertz spectra are compared with the experimental terahertz signature. This work illustrates the importance of terahertz spectroscopy to identify vibrational degrees of freedom which correlate to known conformational changes in these proteins.&lt;/p&gt;</style></abstract><work-type><style face="normal" font="default" size="100%">Article</style></work-type><accession-num><style face="normal" font="default" size="100%">WOS:000254420100030</style></accession-num><notes><style face="normal" font="default" size="100%">ISI Document Delivery No.: 280IP&lt;br/&gt;Times Cited: 50&lt;br/&gt;Cited Reference Count: 72&lt;br/&gt;Cited References: &lt;br/&gt;     Abdulaev NG, 1998, P NATL ACAD SCI USA, V95, P12854, DOI 10.1073/pnas.95.22.12854&lt;br/&gt;     Alexandrov V, 2005, PROTEIN SCI, V14, P633, DOI 10.1110/ps.04882105&lt;br/&gt;     Alexiev U, 2003, J MOL BIOL, V328, P705, DOI 10.1016/S0022-2836(03)00326-7&lt;br/&gt;     Altenbach C, 2001, BIOCHEMISTRY-US, V40, P15493, DOI 10.1021/bi011545o&lt;br/&gt;     AMADEI A, 1993, PROTEINS, V17, P412, DOI 10.1002/prot.340170408&lt;br/&gt;     Balog E, 2004, PHYS REV LETT, V93, DOI 10.1103/PhysRevLett.93.028103&lt;br/&gt;     Beck M, 1998, BIOCHEMISTRY-US, V37, P7630, DOI 10.1021/bi9801560&lt;br/&gt;     Bizzarri AR, 2001, EUR BIOPHYS J BIOPHY, V30, P443, DOI 10.1007/s002490100167&lt;br/&gt;     BROOKS B, 1983, P NATL ACAD SCI-BIOL, V80, P6571, DOI 10.1073/pnas.80.21.6571&lt;br/&gt;     BROOKS BR, 1995, J COMPUT CHEM, V16, P1522, DOI 10.1002/jcc.540161209&lt;br/&gt;     Bu ZM, 2000, J MOL BIOL, V301, P525, DOI 10.1006/jmbi.2000.3978&lt;br/&gt;     Chen JY, 2005, PHYS REV E, V72, DOI 10.1103/PhysRevE.72.040901&lt;br/&gt;     Chen Q, 2001, J OPT SOC AM B, V18, P823, DOI 10.1364/JOSAB.18.000823&lt;br/&gt;     Chung HS, 2005, P NATL ACAD SCI USA, V102, P612, DOI 10.1073/pnas.0408646102&lt;br/&gt;     Crozier PS, 2003, J MOL BIOL, V333, P493, DOI 10.1016/j.jmb.2003.08.045&lt;br/&gt;     Farrens DL, 1996, SCIENCE, V274, P768, DOI 10.1126/science.274.5288.768&lt;br/&gt;     Filippovich S. Y., 2004, PHOTOCHEM PHOTOBIOL, V3, P1&lt;br/&gt;     Fotiadis D, 2006, CURR OPIN STRUC BIOL, V16, P252, DOI 10.1016/j.sbi.2006.03.013&lt;br/&gt;     Gabel F, 2005, BIOPHYS J, V89, P3303, DOI 10.1529/biophysj.105.061028&lt;br/&gt;     Gabel F, 2002, Q REV BIOPHYS, V35, P327, DOI 10.1017/S0033583502003840&lt;br/&gt;     Getmanova E, 2004, BIOCHEMISTRY-US, V43, P1126, DOI 10.1021/bi030120u&lt;br/&gt;     Giraud G, 2003, BIOPHYS J, V85, P1903, DOI 10.1016/S0006-3495(03)74618-9&lt;br/&gt;     GRISCHKOWSKY D, 1991, FEMTOSECOND PULSES T&lt;br/&gt;     Groma GI, 2001, BIOPHYS J, V81, P3432, DOI 10.1016/S0006-3495(01)75975-9&lt;br/&gt;     Hendler RW, 2003, EUR J BIOCHEM, V270, P1920, DOI 10.1046/j.1432-1033.2003.03547.x&lt;br/&gt;     Hu KS, 2000, J PHOTOCH PHOTOBIO B, V58, P163, DOI 10.1016/S1011-1344(00)00125-1&lt;br/&gt;     Humphrey W, 1996, J MOL GRAPH MODEL, V14, P33, DOI 10.1016/0263-7855(96)00018-5&lt;br/&gt;     ICHIYE T, 1991, PROTEINS, V11, P205, DOI 10.1002/prot.340110305&lt;br/&gt;     Jaaskelainen S, 1998, PROTEIN SCI, V7, P1359&lt;br/&gt;     Joti Y, 2004, PHYSICA B, V350, pE627, DOI 10.1016/j.physb.2004.03.167&lt;br/&gt;     Kamikubo H, 1997, BIOCHEMISTRY-US, V36, P12282, DOI 10.1021/bi9712302&lt;br/&gt;     Kataoka M, 2000, BBA-BIOENERGETICS, V1460, P166, DOI 10.1016/S0005-2728(00)00137-7&lt;br/&gt;     Keskin O, 2000, BIOPHYS J, V78, P2093, DOI 10.1016/S0006-3495(00)76756-7&lt;br/&gt;     Kim JE, 2003, BIOCHEMISTRY-US, V42, P5169, DOI 10.1021/bi030026d&lt;br/&gt;     Kim JE, 2002, J PHYS CHEM A, V106, P8508, DOI 10.1021/jp021069r&lt;br/&gt;     Knab J, 2006, BIOPHYS J, V90, P2576, DOI 10.1529/biophysj.105.069088&lt;br/&gt;     KONIG B, 1989, P NATL ACAD SCI USA, V86, P6878, DOI 10.1073/pnas.86.18.6878&lt;br/&gt;     Korter TM, 2006, CHEM PHYS LETT, V418, P65, DOI 10.1016/j.cplett.2005.10.097&lt;br/&gt;     Koutsopoulos S, 2005, PROTEINS, V61, P377, DOI 10.1002/prot.20606&lt;br/&gt;     Langen R, 1999, BIOCHEMISTRY-US, V38, P7918, DOI 10.1021/bi990010g&lt;br/&gt;     Lee AG, 2004, BBA-BIOMEMBRANES, V1666, P62, DOI 10.1016/j.bbamem.2004.05.012&lt;br/&gt;     Li J, 2004, J MOL BIOL, V343, P1409, DOI 10.1016/j.jmb.2004.08.090&lt;br/&gt;     Liang Y, 2003, J BIOL CHEM, V278, P21655, DOI 10.1074/jbc.M302536200&lt;br/&gt;     MacKerell AD, 2001, BIOPOLYMERS, V56, P257&lt;br/&gt;     Markelz A, 2002, PHYS MED BIOL, V47, P3797, DOI 10.1088/0031-9155/47/21/318&lt;br/&gt;     Markelz AG, 2000, CHEM PHYS LETT, V320, P42, DOI 10.1016/S0009-2614(00)00227-X&lt;br/&gt;     McCamant DW, 2005, J PHYS CHEM B, V109, P10449, DOI 10.1021/jp050095x&lt;br/&gt;     Niv MY, 2006, J COMPUT AID MOL DES, V20, P437, DOI 10.1007/s10822-006-9061-3&lt;br/&gt;     Oesterhelt D, 1974, Methods Enzymol, V31, P667&lt;br/&gt;     Okada T, 2001, CURR OPIN STRUC BIOL, V11, P420, DOI 10.1016/S0959-440X(00)00227-X&lt;br/&gt;     Pitman MC, 2005, J AM CHEM SOC, V127, P4576, DOI 10.1021/ja042715y&lt;br/&gt;     Rader AJ, 2004, P NATL ACAD SCI USA, V101, P7246, DOI 10.1073/pnas.0401429101&lt;br/&gt;     Ridge KD, 2003, TRENDS BIOCHEM SCI, V28, P479, DOI 10.1016/S0968-0004(03)00172-5&lt;br/&gt;     Ruprecht JJ, 2004, EMBO J, V23, P3609, DOI 10.1038/sj.emboj.7600374&lt;br/&gt;     Saam J, 2002, BIOPHYS J, V83, P3097, DOI 10.1016/S0006-3495(02)75314-9&lt;br/&gt;     Sass HJ, 2000, NATURE, V406, P649, DOI 10.1038/35020607&lt;br/&gt;     Schmuttenmaer CA, 2004, CHEM REV, V104, P1759, DOI 10.1021/cr020685g&lt;br/&gt;     Siegel PH, 2004, IEEE T MICROW THEORY, V52, P2438, DOI 10.1109/TMTT.2004.835916&lt;br/&gt;     Siegrist K, 2006, J AM CHEM SOC, V128, P5764, DOI 10.1021/ja058176u&lt;br/&gt;     Subramaniam S, 2000, BBA-BIOENERGETICS, V1460, P157, DOI 10.1016/S0005-2728(00)00136-5&lt;br/&gt;     Tajkhorshid E, 2000, BIOPHYS J, V78, P683, DOI 10.1016/S0006-3495(00)76626-4&lt;br/&gt;     Tama F, 2000, PROTEINS, V41, P1&lt;br/&gt;     Tama F, 2002, J MOL BIOL, V321, P297, DOI 10.1016/S0022-2836(02)00627-7&lt;br/&gt;     Tama F, 2001, PROTEIN ENG, V14, P1, DOI 10.1093/protein/14.1.1&lt;br/&gt;     Teller DC, 2001, BIOCHEMISTRY-US, V40, P7761, DOI 10.1021/bi0155091&lt;br/&gt;     Thomas A, 1999, PROTEINS, V34, P96, DOI 10.1002/(SICI)1097-0134(19990101)34:1&lt;96::AID-PROT8&gt;3.0.CO;2-0&lt;br/&gt;     Ujj L, 1998, BIOPHYS J, V74, P1492, DOI 10.1016/S0006-3495(98)77861-0&lt;br/&gt;     Vogel R, 2004, J MOL BIOL, V338, P597, DOI 10.1016/j.jmb.2004.03.006&lt;br/&gt;     Vogel R, 2003, BIOPOLYMERS, V72, P133, DOI 10.1002/bip.10407&lt;br/&gt;     Whitmire SE, 2003, BIOPHYS J, V85, P1269, DOI 10.1016/S0006-3495(03)74562-7&lt;br/&gt;     Yan ECY, 2004, BIOCHEMISTRY-US, V43, P10867, DOI 10.1021/bi0400148&lt;br/&gt;     Zhang J, 2006, PROTEIN PEPTIDE LETT, V13, P33, DOI 10.2174/092986606774502027&lt;br/&gt;Balu, R. Zhang, H. Zukowski, E. Chen, J. -Y. Markelz, A. G. Gregurick, S. K.&lt;br/&gt;Zhang, Hailiang/F-8325-2010&lt;br/&gt;Markelz, Andrea/0000-0003-0443-4319&lt;br/&gt;52&lt;br/&gt;&lt;br/&gt;27&lt;br/&gt;Cell press&lt;br/&gt;Cambridge&lt;br/&gt;1542-0086</style></notes><auth-address><style face="normal" font="default" size="100%">[Balu, R.|Zhang, H.|Zukowski, E.|Gregurick, S. K.] Univ Maryland, Dept Chem &amp; Biochem, Baltimore, MD 21250 USA. [Chen, J. -Y.|Markelz, A. G.] SUNY Buffalo, Dept Phys, Buffalo, NY 14260 USA.&lt;br/&gt;Gregurick, SK (corresponding author), Univ Maryland, Dept Chem &amp; Biochem, Baltimore, MD 21250 USA.&lt;br/&gt;greguric@umbe.edu</style></auth-address></record></records></xml>