<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">He,Y.</style></author><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Knab, J. R.</style></author><author><style face="normal" font="default" size="100%">Zheng, W.</style></author><author><style face="normal" font="default" size="100%">Markelz, A.G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Why is THz Sensitive to Protein Functional States? Oxidation State of Cytochrome C</style></title><secondary-title><style face="normal" font="default" size="100%">Terahertz Science and Technology</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2010</style></year></dates><urls><web-urls><url><style face="normal" font="default" size="100%">http://www.tstnetwork.org/10.11906/TST.149-162.2010.12.15/</style></url></web-urls></urls><volume><style face="normal" font="default" size="100%">3</style></volume><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;We investigate the presence of structural collective motions on a picosecond time scale for the heme protein, cytochrome c, as a function of oxidation and hydration, using terahertz (THz) time-domain spectroscopy and molecular dynamics simulations. Structural collective mode frequencies have been calculated to lie in this frequency range, and the density of states can be considered a measure of flexibility. A dramatic increase in the THz response occurs with oxidation, with the largest increase for lowest hydrations and highest frequencies. For both oxidation states the measured THz response rapidly increases with hydration saturating above ~25% (g H&lt;sub&gt;2&lt;/sub&gt;O/g protein), in contrast to the rapid turn-on in dynamics observed at this hydration level for other proteins. Quasi-harmonic collective vibrational modes and dipole-dipole correlation functions are calculated from the molecular dynamics trajectories. The collective mode density of states alone reproduces the measured hydration dependence providing strong evidence of the existence of these collective motions. The large oxidation dependence is reproduced only by the dipole-dipole correlation function, indicating the contrast arises from diffusive motions consistent with structural changes occurring in the vicinity of a buried internal water molecule.&lt;/p&gt;</style></abstract><issue><style face="normal" font="default" size="100%">4</style></issue><section><style face="normal" font="default" size="100%">149-162</style></section></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>5</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Knab, J. R.</style></author><author><style face="normal" font="default" size="100%">He, Y.</style></author><author><style face="normal" font="default" size="100%">Ye, S.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Development of Tagless Biosensors for Detecting the Presence of Pathogens</style></title><secondary-title><style face="normal" font="default" size="100%">Terahertz Frequency Detection and Identification of Materials and Objects</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2007</style></year></dates><publisher><style face="normal" font="default" size="100%">Springer</style></publisher><pub-location><style face="normal" font="default" size="100%">Dordrecht, The Netherlands</style></pub-location><volume><style face="normal" font="default" size="100%">ed X.-C. Zhang, R. E. Miles, H. Eisele and A. Krotkus</style></volume><pages><style face="normal" font="default" size="100%">123-134</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><section><style face="normal" font="default" size="100%">9</style></section></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Ye, S.</style></author><author><style face="normal" font="default" size="100%">Knab, J.</style></author><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Wang, S.</style></author><author><style face="normal" font="default" size="100%">Cheon, M.</style></author><author><style face="normal" font="default" size="100%">Luo, H.</style></author><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ultrafast Carriers Dynamics in GaSb/Mn Random Alloys</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the 28th International Conference on the Physics of Semiconductors</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year></dates><pub-location><style face="normal" font="default" size="100%">Vienna Austria</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Knab, J. R.</style></author><author><style face="normal" font="default" size="100%">Ye, S.</style></author><author><style face="normal" font="default" size="100%">He, Y.</style></author><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Using terahertz spectroscopy as a protein binding assay</style></title><secondary-title><style face="normal" font="default" size="100%"> Advanced Biomedical and Clinical Diagnostic Systems IV;</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2006</style></year><pub-dates><date><style  face="normal" font="default" size="100%">02/2006</style></date></pub-dates></dates><pub-location><style face="normal" font="default" size="100%"> San Jose, California, United States</style></pub-location><volume><style face="normal" font="default" size="100%">Proc SPIE 6080,</style></volume><pages><style face="normal" font="default" size="100%">35-42</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">&lt;p&gt;The vibrational modes corresponding to protein tertiary structural motion lay in the far infrared or terahertz frequency range. These collective large scale motions depend on global structure and thus will necessarily be perturbed by ligand binding events. We discuss the use of terahertz dielectric spectroscopy to measure these vibrational modes and the sensitivity of the technique to changes in protein conformation, oxidation state and environment. A challenge of applying this sensitivity as a spectroscopic assay for ligand binding is the sensitivity of the technique to both bulk water and water bound to the protein. This sensitivity can entirely obscure the signal from the protein or protein-ligand complex itself, thus necessitating sophisticated sample preparation making the technique impractical for industrial applications. We discuss methods to overcome this background and demonstrate how terahertz spectroscopy can be used to quickly assay protein binding for proteomics and pharmaceutical research.&lt;/p&gt;</style></abstract></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Knab, J. R.</style></author><author><style face="normal" font="default" size="100%">Maeder, M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Measuring Protein Flexibility with Terahertz Spectroscopy: Basic Research and Applications</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the IEEE LEOS Summer Topical Meeting</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">06/2004</style></date></pub-dates></dates><pub-location><style face="normal" font="default" size="100%">San Diego, CA</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Knab, J. R.</style></author><author><style face="normal" font="default" size="100%">Maeder, M.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Thz Dielectric Response As A Function Of Protein Hydration: Intramolecular Coupling Contribution</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of SPIE Optics East</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2004</style></year><pub-dates><date><style  face="normal" font="default" size="100%">10/2004</style></date></pub-dates></dates><pub-location><style face="normal" font="default" size="100%">Philadelphia, PA</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Cerne, J.</style></author><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Biosensing with Terahertz Spectroscopy:  Ligand Binding Effects</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the International Symposium on Spectral Sensing Research </style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2003</style></year></dates><pub-location><style face="normal" font="default" size="100%">Santa Barbara, CA</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Cox, W.</style></author><author><style face="normal" font="default" size="100%">Bright, F. V.</style></author><author><style face="normal" font="default" size="100%">Cerne, J.</style></author><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Terahertz Biosensors based on Xerogel Substrates</style></title><secondary-title><style face="normal" font="default" size="100%">Proceedings of the International Symposium on Spectral Sensing Research</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2003</style></year></dates><pub-location><style face="normal" font="default" size="100%">Santa Barbara, CA</style></pub-location><language><style face="normal" font="default" size="100%">eng</style></language></record><record><source-app name="Biblio" version="7.x">Drupal-Biblio</source-app><ref-type>10</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Chen, J.-Y.</style></author><author><style face="normal" font="default" size="100%">Whitmire, S. E.</style></author><author><style face="normal" font="default" size="100%">Markelz, A. G.</style></author><author><style face="normal" font="default" size="100%">Hillebrecht, J. R.</style></author><author><style face="normal" font="default" size="100%">Birge, R. R.</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">Ultrafast THz spectroscopy of photoactive biomolecules</style></title><secondary-title><style face="normal" font="default" size="100%">Ultrafast Phenomena in Semiconductors VII</style></secondary-title></titles><dates><year><style  face="normal" font="default" size="100%">2003</style></year><pub-dates><date><style  face="normal" font="default" size="100%">01/2003</style></date></pub-dates></dates><pub-location><style face="normal" font="default" size="100%">San Jose, California</style></pub-location><pages><style face="normal" font="default" size="100%">146-153</style></pages><language><style face="normal" font="default" size="100%">eng</style></language></record></records></xml>